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Creators/Authors contains: "Roehner, Nicholas"

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  1. ; ; ; ; ; ; ; ; (, ACS Synthetic Biology)
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  2. ; ; ; ; ; ; (, ACS Synthetic Biology)
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  3. ; ; ; ; ; ; ; (, ACS synthetic biology)
    The iBioSim tool has been developed to facilitate the design of genetic circuits via a model-based design strategy. This paper illustrates the new features incorporated into the tool for DNA circuit design, design analysis, and design synthesis, all of which can be used in a workflow for the systematic construction of new genetic circuits. 
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  4. ; ; ; ; ; ; ; ; ; ; et al (, ACS Synthetic Biology)
    Synthetic biology is creating genetically engineered organisms at an increasing rate for many potentially valuable applications, but this potential comes with the risk of misuse or accidental release. To begin to address this issue, we have developed a system called GUARDIAN that can automatically detect signatures of engineering in DNA sequencing data, and we have conducted a blinded test of this system using a curated Test and Evaluation (T&E) data set. GUARDIAN uses an ensemble approach based on the guiding principle that no single approach is likely to be able to detect engineering with perfect accuracy. Critically, ensembling enables GUARDIAN to detect sequence inserts in 13 target organisms with a high degree of specificity that requires no subject matter expert (SME) review. 
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